Bioengineering

On the trail of cellular mysteries

05/05/10 — UC Berkeley assistant professor of bioengineering Mohammad Mofrad has been busy uncovering the mysteries of how human cells behave when physical force is applied to them, working at the exact intersection of engineering and biology. Mofrad and a handful of fellow researchers are in the vanguard of a subspecialty called cellular mechanobiology, or cellular biomechanics, where they're stirring up the entire field of biology by adding physics to the mix. The ramifications of their work may one day bring about better treatments for cancer and cardiovascular disease as well as HIV/AIDS and the common flu.

Bioengineering professor Luke Lee awarded 2010 Ho-Am Prize in Engineering

04/21/10 Ho-Am Foundation — Lee was recognized for his seminal contributions to bionanoscience, including leadership in bionanophotonics, the discovery of Plasmon Resonance Energy Transfer (PRET) imaging of living cells, gene regulation by nanoplasmonic optical antenna, and label-free molecular diagnostics.

Engineering health reform

04/07/10 — The health care reform bill enacted last month is the most far-reaching domestic policy the nation has seen in decades. Only time will tell us all the ramifications of this historic legislation. As the acting dean of the College of Engineering I ask, how can engineers help patients, physicians and providers make the best use of the changes ahead?

Rubinsky goes global with health care reform

03/03/10 — Inventor, researcher and educator Boris Rubinsky has taken his show on the road. During three prolific decades in Berkeley's labs and classrooms, the professor of bioengineering and mechanical engineering stacked up nearly 40 patents and cofounded half a dozen startups in surgical techniques, bionic technology and imaging. Now Rubinsky is finding inspiration in his new role as health care advocate for the economically disadvantaged, building endorsement for his conviction that inexpensive but scientifically advanced technologies can improve health care for underserved populations.

Science in the Amazon

03/03/10 — The boys from the Amazonian orphanage decided to name themselves Los Científicos. The Scientists. It was a small but monumental achievement for Rick Henrikson and Richard Novak, two Berkeley bioengineering graduate students. The pair cofounded Future Scientist, a tiny but highly motivated aid organization whose mission is to teach science and practical technical skills to young people in rural, developing regions. Last August, Novak, Henrikson and nine other Future Scientists traveled to Peru for their first pilot project: teaching a two-week crash course on pathogenic microorganisms, disease transmission, optics and solar-powered electricity to schoolchildren living along the Amazon River. This slideshow tells their story.

TMS 2010: Bone-like structural materials – how can we do them?

02/18/10 Material Views — In his IoM Franklin Mehl Award lecture this morning, Robert Ritchie, professor of materials science at UC Berkeley, took his audience on a tour de force through the cutting edge of scientific research on mechanical behavior of biological materials and the potential to synthetically produce nature-like structural materials

Anti-medical school, pro health

02/03/10 — No offense to medical schools, but students last fall liked taking "Anti-Medical School," a new graduate seminar at Berkeley. While medical schools generally teach what is known in medicine, Anti-Medical School explores what is unknown and unsolved in medicine, and that's what students found compelling. At each weekly lecture, like the one on Alzheimer's taught by neurologist and neuroscientist Adam Gazzaley, a UCSF physician presents a problem in need of an engineering solution in hopes of engaging the students in solving thorny, real-world clinical challenges as part of their master's or doctorate research.

Berkeley Bioengineering professor Mohammad Mofrad Receives NSF CAREER Award

01/29/10 National Science Foundation — Berkeley Bioengineering Assistant Professor Mohammad Mofrad has received a 2010 National Science Foundation Faculty Early Career Development (CAREER) Program award. CAREER awards are given to young researchers in science and engineering who have also translated their work into significant education activities.

Bacteria transformed into biofuel refineries

01/27/10 Scientific American — The bacteria responsible for most cases of food poisoning in the U.S. has been turned into an efficient biological factory to make chemicals, medicines and, now, fuels. UC Berkeley bioengineering professor Jay Keasling and his colleagues have manipulated the genetic code of Escherichia coli, a common gut bacteria, so that it can chew up plant-derived sugar to produce diesel and other hydrocarbons.

DNA factory launches

01/21/10 TheScientist.com — California synthetic biologists are launching a production facility that will provide free, standardized DNA parts for scientists around the world. BIOFAB aims to boost the ease of bioengineering with "biological parts" that are shared resources, standardized and reliable enough that they can be switched in and out of a genome like electronic parts in a radio. Adam Arkin, BIOFAB's codirector and a professor of bioengineering at UC Berkeley, says the group has already hired scientists who are in the lab, making constructs.

Leaders in science, advocacy, media to judge 2010 Biotech Humanitarian Award

01/05/10 Biotechnology Industry Organization — The Biotechnology Industry Organization (BIO) announced a distinguished panel of judges -- including Jay Keasling, professor of bioengineering at UC Berkeley -- to evaluate nominations for The Biotech Humanitarian Award and select the 2010 Honoree. BIO created the award to recognize an everyday hero who has helped to heal, fuel and feed the planet through their work in the broad biotech arena.

Meet the Next Builder of Berkeley Bioengineering

10/08/09 — After 32 years at other universities, Matthew Tirrell joined Berkeley in July, and from his new Stanley Hall office, he ruminates on the job he's just taken, that of Department of Bioengineering chair. "A chair's creativity is needed when faculty members want help getting their ideas enacted -- that's enabling. And sometimes a chair gets a good idea of his or her own and has a chance to lead. Managing is fine, but I like enabling and leading best. I'd like to help this department define what it could be."

Preserving Vision with Hydrogel

08/02/08 — High axial myopia, or extreme nearsightedness, is one of the world's leading causes of blindness. The condition stems from weakness in the sclera, the eyeball's white outer wall, which causes it to deform even under normal pressure within the eyeball. James Su, a graduate student researcher co-advised by MSE and Bioengineering Professor Kevin Healy and School of Optometry Professor Christine Wildsoet, is developing a promising new treatment for the condition, based on a synthetic biomaterial known as hydrogel.

Striking a Nerve

06/02/08 — Nanofibers that create a miniature scaffold for growing cells could soon help patients regenerate severed nerves in their arms and legs, says Shyam Patel, chief scientific officer for a Fremont startup called NanoNerve. Patel is developing a synthetic graft intended to guide neurons across gaps and restore lost connections in nerves serving limbs and other parts of the peripheral nervous system. In the United States alone, an estimated 800,000 people a year experience peripheral nerve injuries that require surgery and that can lead to a loss of sensation and movement. The new device-a flexible conduit that resembles a slender white straw-could open a new treatment option.

Students Grab Gold with Bacteria-to-Blood Project

02/02/08 — A team of Cal undergraduates has demonstrated how genetically modified E. coli bacteria might be converted into a cheap-and safe-blood substitute. The engineered product, called “Bactoblood,” addresses a global shortage of human blood for transfusions, particularly in developing countries and emergency situations, the young developers say.

Re-engineering Bioproduction

01/02/08 — As the biotech industry has grown, Professors Lee Schruben, Rob Leachman and Phil Kaminsky of Berkeley's Department of Industrial Engineering and Operations Research (IEOR) have watched the young field bring lifesaving new drugs to market. They have also seen that their potential benefit to society isn't always realized when these drugs are priced out of reach or when stocks run short. Recognizing that some good IEOR principles could address these problems, they organized the first NSF symposium on Biomanufacturing and Logistics Systems in 2006.